The US State Department has issued a worldwide alert urging American citizens to exercise caution while traveling or living abroad, as tensions linked to the Iran conflict intensify.

The advisory warns of potential airspace closures and travel disruptions, asking Americans overseas to closely follow security updates from the nearest US embassy or consulate. It also highlights the risk of US diplomatic facilities being targeted—even outside the Middle East—and cautions that groups supportive of Iran could attack American interests globally.

The alert comes amid signs that the conflict may persist. US Treasury Secretary Scott Bessent indicated that the war could continue for some time, while defending a tougher US stance. Earlier, President Donald Trump issued a 48-hour ultimatum to Iran to reopen the Strait of Hormuz, warning of strikes on key infrastructure if demands are not met.

Iran has responded with its own warnings. A spokesperson for its military command said any attack on Iranian energy infrastructure would be met with retaliatory strikes targeting US-linked fuel, energy, and technology systems in the region.

This is not the first such global advisory since the conflict began. Following the initial US-Israel strikes on Iran on February 28, Washington had already issued a similar “worldwide caution,” advising Americans to remain vigilant and prepare for disruptions caused by escalating hostilities.

The latest alert underscores growing concerns that the conflict’s impact could extend far beyond the Middle East, affecting travel, security, and US interests worldwide.